Funding National Natural Science Foundation of China (82001166 and 82171186)
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In relation to the clinical use of GLP-1R agonists for the treatment of PD, pharmacokineticpharmacodynamic correlations of each GLP-1R agonist, from relatively short acting exenatide (in the form of Byetta [twice daily] and sustained release Bydureon [once weekly]) to longer acting dulaglutide, should be closely examined as to their potency, selectivity, bloodbrain barrier (BBB) penetration, and tolerability, which may be very different from one another and ultimately impact their efficacy in PD
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Doll S, Freitas FP, Shah R, et al